AOD-9604: synthetic hGH fragment 177-191 peptide (≥98% purity). β3-adrenergic receptor modulator for lipolysis research. Laboratory use only. Not for human consumption.
Compound: 29-amino acid synthetic GHRH(1-29)-NH₂; biologically active N-terminal fragment of human growth hormone-releasing hormone
Mechanism: Binds GHRH-R on pituitary somatotrophs; activates Gs-cAMP-PKA-CREB signaling cascade for physiological pulsatile GH release under somatostatin feedback regulation
Validation: Authorized 1990 (diagnostic) and 1997 (pediatric GH deficiency); extensively characterized in peer-reviewed endocrinology, neuroendocrinology, and oncology research
Synthetic GHRH Analog: 44-amino acid polypeptide with N-terminal trans-3-hexenoic acid modification; enhanced DPP-IV resistance extends half-life to 26–38 min vs. minutes for native GHRH; 150+ PubMed publications
Physiological GH Axis Modulation: Selective GHRH-R agonist preserving pulsatile GH secretion patterns and IGF-1 feedback regulation; studied in clinical trials for metabolic effects in HIV-associated lipodystrophy
Regulatory Status: Tesamorelin (Egrifta) authorized 2010 for HIV-associated lipodystrophy; Egrifta WR (F8 formulation) authorized March 2025 with reconstitution updates; ongoing research in neurocognitive and hepatic biology