HCG (5000) Glycoprotein Hormone (hCG): 237-amino acid heterodimer (α-subunit 92 aa + β-subunit 145 aa), ≥95% purity by SDS-PAGE, 5,000 IU per vial LHCGR Biased Agonism: cAMP/PKA steroidogenic signaling, EC₅₀ 107 pM — 5-fold more potent than LH for cAMP production Reproductive Endocrinology Research: GPCR signaling, steroidogenesis, and endometrial biology investigation Manufacturer: RiboCore Availability: 100 in stock SKU: RP-HCG $54.00 Qty: Add to cart Ship to Select country United States of America Afghanistan Åland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia (Plurinational State of) Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cabo Verde Cambodia Cameroon Canada Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo (Democratic Republic of the) Cook Islands Costa Rica Côte d'Ivoire Croatia Cuba Curaçao Cyprus Czechia Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Eswatini Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See Honduras Hong Kong Hungary Iceland India Indonesia Iran (Islamic Republic of) Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea (Democratic People's Republic of) Korea (Republic of) Kuwait Kyrgyzstan Lao People's Democratic Republic Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Micronesia (Federated States of) Moldova (Republic of) Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Palestine, State of Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Puerto Rico Qatar Réunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Sweden Switzerland Syrian Arab Republic Taiwan, Province of China Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom of Great Britain and Northern Ireland United States Minor Outlying Islands Uruguay Uzbekistan Vanuatu Venezuela (Bolivarian Republic of) Vietnam Virgin Islands (British) Virgin Islands (U.S.) Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe * Other * Shipping Method Name Estimated Delivery Price No shipping options Apply Custom wishlist OK Add to wishlist Add to compare list Email a friend Technical Specifications CharacteristicValue CAS Number9002-61-3 Molecular Weight~36,700 Da (intact heterodimer with glycans) Subunit Compositionα-subunit 92 aa + β-subunit 145 aa Purity≥95% (SDS-PAGE) FormLyophilized powder, white to off-white, 5,000 IU per vial Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone comprising 237 amino acids, supplied as a lyophilized powder for in vitro research and intended strictly for qualified researchers. Originally characterized as the primary luteotropic signal of early pregnancy, hCG is recognized as a pleiotropic molecule investigated across reproductive endocrinology, GPCR pharmacology, steroidogenesis, immunomodulation, angiogenesis, and endometrial biology. With thousands of indexed peer-reviewed publications, hCG ranks among the most thoroughly characterized hormones in biomedical research. Key Research Highlights Research AreaKey Finding LHCGR ActivationCryo-EM structures of full-length LHCGR-hCG-Gs complex reveal "push-and-pull" activation mechanism with conserved tethered agonist peptide P10 (Duan et al., 2021, Nature) Biased AgonismhCG 5-fold more potent than LH for cAMP (EC₅₀ 107 pM vs. 530 pM); hCG biased toward sustained cAMP/PKA steroidogenic signaling vs. LH ERK1/2 preference (Casarini et al., 2012) Endometrial BiologyhCG-activated LHCGR increases HOXA10, ITGB3, FOXO1, and LIF expression; modulates autophagy via ERK1/2 and mTOR; epigenetic H3K27Ac changes at decidualization-associated genes (Wang et al., 2024; Žukauskaite et al., 2025) Research Applications GPCR biased agonism and LHCGR signaling studies Steroidogenesis and StAR protein pathway investigation Reproductive endocrinology and spermatogenesis models Endometrial receptivity and epigenetic regulation research Maternal-fetal immune tolerance investigation Angiogenesis and EG-VEGF pathway studies Research Use Only. This product is supplied for in vitro laboratory investigation by qualified researchers. Not for human or veterinary consumption, diagnosis, treatment, prevention, or cure of any condition. Not approved by the FDA for human use.
