Ipamorelinis a synthetic pentapeptide growth hormone secretagogue that selectively binds the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor. In experimental models, Ipamorelin activates Gq/PLC-dependent calcium signaling pathways that stimulate growth hormone release while demonstrating minimal activity on other pituitary hormones, including ACTH, prolactin, FSH, LH, TSH, and cortisol. Due to its high receptor selectivity, Ipamorelin is widely utilized in rese
Universal Redox Coenzyme: Central to 500+ enzymatic reactions, glycolysis, citric acid cycle, electron transport chain, 80,000+ PubMed publications since 1906 discovery
Sirtuin/PARP/CD38 Substrate: Essential cofactor for SIRT1-7 longevity proteins, PARPs for DNA repair, CD38 calcium signaling; NAD+ declines 10-65% with aging across tissues
Clinical Development: Multiple Phase 2 RCTs showing 2.6-3.1x NAD+ increases with precursor supplementation, benefits in metabolic disease, cognition, long COVID, well-tolerated safety profile