L-Glutathione 600mg

Master Antioxidant Tripeptide: L-γ-Glu-L-Cys-Gly sequence, ≥98% purity
Cellular Redox Homeostasis: Primary intracellular thiol buffer (0.5-10 mM)
Phase II Detoxification: GST-mediated conjugation and xenobiotic metabolism studies

Manufacturer: RiboCore

Availability: In stock

SKU: RC-GLUT-1500MG

$60.00

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Technical Specifications

Characteristic	Value
CAS Number	70-18-8
Molecular Weight	307.32 Da
Molecular Formula	C₁₀H₁₇N₃O₆S
Sequence	gamma-L-Glu-L-Cys-Gly (3 amino acids)
Purity	≥98% (HPLC)
Form	Crystalline powder

Glutathione (GSH, L-gamma-glutamyl-L-cysteinyl-glycine) is an endogenous tripeptide composed of glutamic acid, cysteine, and glycine. First identified by Sir Frederick Gowland Hopkins in 1921, it is the most abundant low-molecular-weight thiol in mammalian cells and the principal non-protein antioxidant synthesized intracellularly. With over 180,000 publications indexed in PubMed, glutathione occupies a central position in cellular redox homeostasis, xenobiotic detoxification, immune regulation, and signal transduction.

Glutathione possesses a unique gamma-peptide bond between the gamma-carboxyl group of glutamate and the alpha-amino group of cysteine, conferring resistance to degradation by most intracellular peptidases. The cysteine residue contains a free sulfhydryl (-SH) group that serves as the molecule's reactive center, enabling it to act as a nucleophile in conjugation reactions, participate in disulfide exchange, and reduce oxidized species through electron donation.

Key Research Highlights

Research Area	Key Finding
Oral Supplementation	1000 mg/day for 6 months increased GSH levels 30-35% in erythrocytes, plasma, and lymphocytes (Richie et al., 2015)
Immune Function	Natural killer cell cytotoxicity increased >2-fold with oral GSH; liposomal formulation showed up to 400% increase (Sinha et al., 2018)
Aging	Elderly subjects had 46% lower GSH with 45% slower synthesis rates; supplementation restored levels to young-adult ranges (Sekhar et al., 2011)
Diabetes	500 mg daily improved HbA1c and decreased oxidative DNA damage (Cohen's d = -1.07) in elderly diabetic patients (Kalamkar et al., 2022)

Research Applications

Oxidative stress and redox biology research (GSH/GSSG ratio measurement)
Xenobiotic metabolism and Phase II detoxification studies
Neurodegenerative disease research (Parkinson's, Alzheimer's, ALS)
Immune function and inflammatory pathway investigation
Aging and longevity pathway research
Mitochondrial function and bioenergetics
Hepatoprotection and drug-induced liver injury models
Drug delivery and bioavailability enhancement studies