SNAP-8

SNAP-8 - SNARE Complex Modulating Research Peptide Molecular Profile: SNAP-8 is a synthetic octapeptide with sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂, molecular formula C₄₁H₆₅N₁₅O₁₆S, approximate molecular weight 1,075.12 Da, and CAS 868844-74-0. The peptide is designed as an analog of the N-terminal domain of SNAP-25 (synaptosomal-associated protein, 25 kDa), a key component of the SNARE complex mediating vesicular neurotransmitter release. Mechanism of Action: SNAP-8 modulates SNARE complex assembly by competing with native SNAP-25 for incorporation into the synaptic fusion machinery. The SNARE complex (comprising SNAP-25, syntaxin, and VAMP/synaptobrevin) is essential for calcium-triggered vesicle fusion and neurotransmitter exocytosis at the neuromuscular junction. By interfering with SNARE complex formation, SNAP-8 may reduce vesicular acetylcholine release and subsequent muscle contraction signaling. Research Applications: This research-grade peptide supports investigation of SNARE complex biology, synaptic vesicle fusion mechanisms, neuromuscular junction physiology, and exocytosis regulation. Product Specifications: - Purity: ≥98% (HPLC verified) - Form: Lyophilized powder - Storage: -20°C, protected from light and moisture - Certificate of Analysis provided Laboratory Use Only: This product is intended strictly for in-vitro research applications. NOT FOR HUMAN CONSUMPTION. Intended for qualified researchers and licensed laboratory facilities only.