Semax (10 mg)

ACTH(4-10) Heptapeptide Analogue: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP); ≥98% purity by HPLC; Pro-Gly-Pro C-terminal extension confers enhanced metabolic stability vs. native ACTH(4-10)
Multi-Pathway Neurotrophin Research: BDNF upregulation (1.4× protein, 3× mRNA in hippocampus at 50 μg/kg), serotonergic modulation (180% extracellular 5-HIAA), copper chelation (K_D 1.3×10⁻¹⁵ M), anti-amyloid activity
800+ Peer-Reviewed Publications: Neuroprotection, cerebrovascular, neurotrophic factor, and transcriptomic ischemia research; registered pharmaceutical in Russia since 2011

Manufacturer: RiboCore

Availability: 100 in stock

SKU: RP-SEMAX-10MG

$35.00

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Technical Specifications

Characteristic	Value
CAS Number	80714-61-0
Molecular Weight	813.92 Da
Molecular Formula	C₃₇H₅₁N₉O₁₀S
Purity	≥98% (HPLC)
Form	Lyophilized powder
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro

Semax (ACTH(4-7)-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the adrenocorticotropic hormone (ACTH) fragment (4-10), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The N-terminal Met-Glu-His-Phe tetrapeptide retains the ACTH(4-7) pharmacophore, while the Pro-Gly-Pro C-terminal extension confers resistance to aminopeptidase and carboxypeptidase degradation and substantially extends biological half-life compared to the parent fragment. Notably, Semax does not exhibit the hormonal corticotropic activity of full-length ACTH. Supplied as a lyophilized powder for in vitro research, intended strictly for qualified researchers.

Key Research Highlights

Research Area	Key Finding
BDNF/TrkB Upregulation	1.4-fold BDNF protein, 3-fold exon III BDNF mRNA, 2-fold trkB mRNA in rat hippocampus at 50 μg/kg intranasal (Dolotov et al., 2006)
Serotonergic Modulation	Extracellular 5-HIAA rose to ~180% at 1–4 hours post-administration in rodent striatum (Eremin et al., 2005)
Copper Chelation / Anti-Amyloid	K_D 1.3×10⁻¹⁵ M for Cu²⁺; inhibits Aβ fibrillation; 90% SH-SY5Y cytoprotection from Aβ oligomers (Sciacca et al., 2022)
Ischemia-Transcriptomic Protection	394 differentially expressed genes post-ischemia-reperfusion; suppressed Il1a, Il1b, Il6; activated neurotransmission genes (Filippenkov et al., 2020)

Research Applications

Neurotrophic factor biology (BDNF/TrkB, NGF signaling)
Cerebral ischemia and neuroprotection research
Neurodegenerative disease models (amyloid-beta, copper dysregulation)
Monoaminergic neurotransmitter research
Stress and mood disorder research
Ophthalmic neuroprotection research
Melanocortin receptor pharmacology (MC4R/MC5R)

Research Use Only. This product is supplied for in vitro laboratory investigation by qualified researchers. Not for human or veterinary consumption, diagnosis, treatment, prevention, or cure of any condition. Not approved by the FDA for human use.