PEG-MGF (2mg)

PEG-MGF (PEGylated Mechano Growth Factor) is a synthetic, PEG-conjugated form of the Mechano Growth Factor (MGF) E-domain peptide, a 24-amino acid C-terminal fragment derived from the IGF-1Ec splice variant of the insulin-like growth factor 1 gene. MGF was first identified when increased expression of a distinct IGF-1 mRNA isoform was observed in skeletal muscle following mechanical stress. The IGF-1 gene generates multiple mRNA variants through alternative splicing; the IGF-1Ec transcript contains a unique insert that produces a completely different C-terminal E-domain sequence compared to systemic IGF-1Ea.

Research demonstrates MGF signals through MAPK-ERK1/2 pathways independently of the canonical IGF-1 receptor (IGF-1R), activating quiescent muscle satellite (stem) cells while inhibiting premature differentiation. Studies show MGF promotes myoblast proliferation, enhances satellite cell activation and fusion potential, and increases proliferative lifespan of muscle progenitor cells. Beyond muscle biology, MGF demonstrates neuroprotective effects through PKCε/Nrf2/HO-1 signaling in dopaminergic neurons and modulates cardiac function via 14-3-3 protein interactions.

The PEGylation modification (covalent attachment of polyethylene glycol chains) extends the biological half-life from minutes to hours by shielding the peptide from proteolytic degradation and reducing renal clearance. This research-grade PEGylated variant is provided at >98% purity for investigations of satellite cell biology, muscle regeneration, neuroprotection, and cardiac repair mechanisms.

This product is intended strictly for research purposes and is not for human or veterinary use.