Methylene Blue (20mg) (50 caps)

Phenothiazine Compound: Synthetic small-molecule (319.85 Da), ≥98% purity by HPLC
Mitochondrial Electron Carrier: Complex IV stimulation and Nrf2/AKT signaling research
Neuroprotection Models: Tau aggregation, NLRP3 inflammasome, and mitophagy investigation

Manufacturer: RiboCore

Availability: 100 in stock

SKU: RP-METH-20MG

$55.00

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Technical Specifications

Characteristic	Value
CAS Number	61-73-4
Molecular Formula	C₁₆H₁₈ClN₃S
Molecular Weight	319.85 Da
Purity	≥98% (HPLC verified, USP/EP grade)
Form	Dark blue gelatin capsules (20 mg per capsule, 50 caps)

Methylene Blue (methylthioninium chloride) is a synthetic phenothiazine compound first prepared by Heinrich Caro in 1876, making it among the longest-studied small molecules in pharmacology. This product is supplied as 20 mg oral capsules of ≥98% pharmaceutical-grade methylthioninium chloride for in vitro research and animal model investigation. Certificate of Analysis (CoA) provided with every lot. Intended strictly for qualified researchers — not for human or veterinary consumption.

Key Research Highlights

Research Area	Key Finding
Mitochondrial Bioenergetics	Increases Complex IV activity ~30%; bypasses Complexes I/III electron leak (Atamna et al., 2008)
Nrf2/AKT Signaling	Activates antioxidant response element gene expression independent of electron carrier function (Bhurtel et al., 2021)
Inflammasome Research	Inhibits NLRP3, NLRC4, AIM2 inflammasome platforms in microglial models (Lin et al., 2017)
Tau Aggregation	Inhibits tau–tau binding interactions in vitro (Congdon et al., 2012)

Research Applications

Mitochondrial electron transport chain dysfunction studies
Neurodegenerative disease cell and animal models
NLRP3 and multi-inflammasome pathway research
Tau and amyloid-beta aggregation in vitro assays
Senescence-pathway and fibroblast longevity-mechanism research
Antimicrobial photodynamic therapy investigation
Cerebral ischemia and mitophagy induction studies

Research Use Only. This product is supplied for in vitro laboratory investigation by qualified researchers. Not for human or veterinary consumption, diagnosis, treatment, prevention, or cure of any condition. Not approved by the FDA for human use.