KISSPEPTIN (10mg)

Master Reproductive Regulator: C-terminal decapeptide (YNWNSFGLRF-NH2), ≥95% purity
KISS1R/GPR54 Agonist: 8-fold higher receptor affinity than kisspeptin-54 (Ki = 0.042 nM)
GnRH Pulse Generator: Most potent GnRH neuron stimulator, 4-minute human plasma half-life

Manufacturer: RiboCore

Availability: 100 in stock

SKU: RP-KISS-10MG

$55.00

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Technical Specifications

Characteristic	Value
CAS Number	374675-21-5
Molecular Weight	1302.44 Da
Molecular Formula	C₆₃H₈₃N₁₇O₁₄
Sequence	Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Purity	≥95% (HPLC)
Form	Lyophilized powder

Kisspeptin-10 (KP-10, Metastin 45-54) is a biologically active decapeptide derived from the C-terminal region of the KISS1 gene product, representing the minimal structural fragment required for full agonist activity at the KISS1R (GPR54) receptor. Since the landmark 2003 discovery that loss-of-function mutations in GPR54 cause idiopathic hypogonadotropic hypogonadism in humans, kisspeptin has been recognized as a master regulator of mammalian reproduction. More than 5,000 peer-reviewed publications reference the kisspeptin system.

Kisspeptin-10 exhibits approximately 8-fold higher binding affinity for KISS1R compared to the full-length kisspeptin-54 peptide (Ki = 0.042 nM versus 0.34 nM), making it a preferred pharmacological tool for investigating KISS1R signaling pathways. The C-terminal amidation (-NH2) on the Phe10 residue is essential for biological activity, and the Trp3 and Phe6/Phe10 residues form the hydrophobic pharmacophore critical for receptor recognition.

Key Research Highlights

Research Area	Key Finding
LH Stimulation (Men)	IV bolus KP-10 (1 μg/kg) increased LH from 4.1 to 12.4 IU/L at 30 min; continuous infusion (4 μg/kg/h) raised LH from 5.5 to 20.9 IU/L and testosterone from 16.6 to 24.0 nmol/L (George et al., 2011)
Ovulation Control	Absolutely required for preovulatory LH surge; Gpr54-null mice show complete absence of ovulation (Clarkson et al., 2008)
IVF Application	Kisspeptin-54 triggered egg maturation in 97% of IVF patients with 32% live birth rate and lower OHSS risk (Sharma et al., 2022)
Sexual Desire	KP-54 infusion increased penile tumescence 56% and modulated sexual brain processing in men with HSDD (Mills et al., 2023)
Intranasal Delivery	First demonstration of intranasal KP-54 (12.8 nmol/kg) robustly stimulating gonadotropins with no adverse events (Mills et al., 2025)

Research Applications

Reproductive neuroendocrinology and GnRH neuron electrophysiology
KISS1R/GPR54 receptor pharmacology and dual G protein coupling
KNDy neuronal network and GnRH pulse generator mechanisms
Fertility and assisted reproduction (IVF oocyte maturation triggering)
Male reproductive physiology and metabolic hypogonadism
Sexual medicine and psychoneuroendocrinology (HSDD treatment)
Metabolic-reproductive integration and energy balance
Cancer biology and metastasis suppression (KISS1 gene)
Cerebrovascular research (aneurysm prevention, atherosclerosis)
Immunology and autoimmune disease (NF-κB signaling modulation)