GHK-Cu Capsules (3mg) 60 capsules

GHK-Cu Oral Capsules: Gly-His-Lys copper(II) complex, 3mg/capsule × 60, ≥98% purity by HPLC
TGF-β / NF-κB Pathway Research: ECM remodeling, NF-κB anti-inflammatory signaling studies
Oral Pharmacokinetics Studies: GI bioavailability and SIRT1/STAT3 colitis-model research

Manufacturer: RiboCore

Availability: 100 in stock

SKU: RP-GHK-3MG

$84.00

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Technical Specifications

Characteristic	Value
CAS Number	49557-75-7
Molecular Weight (Cu complex)	403.92 Da
Molecular Formula (Cu complex)	C₁₄H₂₄CuN₆O₄
Purity	≥98% (HPLC)
Form	Oral capsules, 3mg per capsule, 60 capsules per bottle

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper(II)) is a naturally occurring tripeptide-copper complex first isolated from human plasma albumin in 1973 by Dr. Loren Pickart at UCSF. Intended strictly for qualified researchers as an investigational research compound, it has been the subject of over 100 peer-reviewed publications documenting extracellular matrix remodeling, anti-inflammatory signaling, antioxidant defense, and genome-wide gene-expression research. This oral capsule format (3mg × 60) is supplied for research into oral peptide pharmacokinetics, gastrointestinal bioavailability, and intestinal epithelial cell biology.

Key Research Highlights

Research Area	Key Finding
Oral GI Colitis Model	Oral gavage at 20 mg/kg in DSS-induced colitis mice: SIRT1/STAT3 pathway modulation, restored ZO-1/Occludin, suppressed TNF-α, IL-6, IL-1β (Mao et al., 2025)
Genome-Wide Gene Modulation	31.2% of human genes show ≥50% expression change; 47 DNA-repair genes and 16/18 antioxidant genes upregulated (Broad Institute CMap; Pickart & Margolina, 2018)
Antioxidant Enzyme Research	Reduces ferritin iron release by 87%; direct scavenging of 4-HNE, acrolein, and MDA; Nrf2 pathway activation (Pickart et al., 2012)

Research Applications

Oral peptide pharmacokinetics and GI bioavailability
NF-κB and SIRT1/STAT3 anti-inflammatory pathway research
TGF-β signaling and ECM remodeling studies
Nrf2 antioxidant pathway investigation
Genome-wide transcriptomic profiling in aging-biology models
Neuroprotection and neuroinflammation research

Research Use Only. This product is supplied for in vitro laboratory investigation by qualified researchers. Not for human or veterinary consumption, diagnosis, treatment, prevention, or cure of any condition. Not approved by the FDA for human use.