BAM15

BAM15 - Selective Mitochondrial Uncoupler Research Compound Molecular Profile: BAM15 is a potent, selective mitochondrial protonophore uncoupler with IUPAC name N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine. Molecular formula C₁₆H₁₀F₂N₆O, molecular weight 340.29 Da, CAS 210302-17-3. Unlike classical uncouplers such as FCCP, BAM15 demonstrates selectivity for mitochondrial membranes without depolarizing plasma membranes. Mechanism of Action: BAM15 functions as a lipophilic weak acid protonophore that transports protons into the mitochondrial matrix via a pathway independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. EC₅₀ = 270 nM in L6 myoblast mitochondria. Critically, BAM15 stimulates higher maximum mitochondrial respiration rates than FCCP while preserving plasma membrane potential and demonstrating lower cytotoxicity. Does not require adenine nucleotide translocase (ANT) for activity. Research Applications: This compound supports investigation of mitochondrial uncoupling mechanisms, energy expenditure, obesity research, ischemia-reperfusion injury protection, and metabolic disease models. Product Specifications: - Purity: ≥98% (HPLC verified) - Form: Powder - Storage: -20°C, protected from light and moisture - Certificate of Analysis provided Laboratory Use Only: This product is intended strictly for in-vitro research applications. NOT FOR HUMAN CONSUMPTION. Investigational compound. Intended for qualified researchers only.