MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically within the 12S ribosomal RNA gene. Unlike traditional nuclear-encoded proteins, MOTS-c represents a novel class of signaling molecules called mitochondrial-derived peptides (MDPs) that act as retrograde signaling factors communicating metabolic status from mitochondria to the nucleus.

Research demonstrates MOTS-c's role as a metabolic regulator that enhances insulin sensitivity, promotes glucose uptake in skeletal muscle, and activates the AMPK signaling pathway. Studies show it regulates cellular energy homeostasis, mitochondrial function, and metabolic adaptation to stress. MOTS-c translocates to the nucleus during metabolic stress to regulate nuclear gene expression and coordinate cellular responses.

This research-grade peptide is provided at >98% purity for laboratory use in metabolic research, mitochondrial biology studies, and investigations of mitochondrial-nuclear communication pathways.

This product is intended strictly for research purposes and is not for human or veterinary use.