Tesofensine

Tesofensine (NS2330) - Triple Monoamine Reuptake Inhibitor Research Compound Molecular Profile: Tesofensine is a phenyltropane-class triple monoamine reuptake inhibitor with molecular formula C₁₇H₂₃Cl₂NO, molecular weight 328.28 g/mol, and CAS 195875-84-4. The bicyclic tropane structure features a bis(4-chlorophenyl)methoxy substituent conferring potent and balanced inhibition of all three monoamine transporters. Mechanism of Action: Tesofensine potently inhibits serotonin (SERT), norepinephrine (NET), and dopamine (DAT) transporters with IC₅₀ values of 11 nM, 1.7 nM, and 8-65 nM respectively. This triple reuptake inhibition increases synaptic monoamine concentrations, modulating lateral hypothalamic GABAergic neurons involved in feeding behavior through α1 adrenoceptor and dopamine D1 receptor pathway stimulation. The compound has an exceptionally long half-life of ~9 days (220 hours), primarily metabolized by CYP3A4. Research Applications: This research-grade compound supports investigation of monoamine transporter pharmacology, appetite regulation mechanisms, central nervous system reward pathways, and thermogenesis research. Product Specifications: - Purity: ≥98% (HPLC verified) - Form: Crystalline powder - Storage: -20°C, protected from light and moisture - Certificate of Analysis provided Laboratory Use Only: This product is intended strictly for in-vitro research applications. NOT FOR HUMAN CONSUMPTION. Investigational compound in Phase III clinical trials. Intended for qualified researchers only.