Selank

Selank Research Peptide Molecular Profile: Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) Molecular Formula: C₃₃H₅₇N₁₁O₉ Molecular Weight: 751.9 Da CAS Number: 129954-34-3 Purity: ≥98% (HPLC) Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory tetrapeptide tuftsin, incorporating a C-terminal Pro-Gly-Pro extension that confers enhanced metabolic stability and bioactivity. Developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank serves as a research tool for investigating GABAergic neurotransmission, neurotrophic signaling, and neuroimmune interactions. Mechanism of Action: • GABA-A Receptor Allosteric Modulation: Functions as positive allosteric modulator enhancing GABAergic inhibitory neurotransmission through effects on Gabra6 and Slc6a13 gene expression • BDNF Expression: Upregulates brain-derived neurotrophic factor (BDNF) mRNA and protein levels in hippocampus and frontal cortex, promoting neuroplasticity • Monoamine Modulation: Influences serotonin, dopamine, and norepinephrine metabolism in key brain regions • Enkephalinase Inhibition: Inhibits enkephalin-degrading enzymes, preserving endogenous opioid peptide activity • Immunomodulatory Activity: Modulates IL-6 and TNF-α expression through tuftsin receptor interactions Research Applications: Selank's multi-modal neurochemical activity enables investigation of anxiolytic mechanisms, GABA system neuroscience, neurotrophic factor signaling, cognitive enhancement pathways, stress neurobiology, neuroimmune interactions, and comparative pharmacology of GABAergic modulators. Product Specifications: • Physical Form: White to off-white lyophilized powder • Quality Control: HPLC, Mass Spectrometry, NMR verification • Storage: -20°C for long-term stability • Solubility: Soluble in sterile water and DMSO • Certificate of Analysis (COA): Provided with each batch FOR RESEARCH AND LABORATORY USE ONLY. NOT FOR HUMAN OR VETERINARY USE. Selank (CAS 129954-34-3) is provided exclusively as a research chemical for in vitro and in vivo laboratory studies. This product is NOT approved by the FDA, EMA, or other regulatory authorities for human therapeutic use, diagnostic purposes, or veterinary applications. Intended solely for qualified researchers in academic and institutional settings conducting legitimate scientific research under appropriate ethical approval. Researchers must comply with institutional biosafety guidelines, use appropriate PPE, and follow proper handling protocols. The purchaser assumes full responsibility for compliance with all applicable regulations and confirms this product will be used exclusively for legitimate research purposes.