Retatrutide (5mg) Triple-Receptor Agonist: 39-amino acid synthetic peptide, 4,731.33 Da, ≥95% purity by HPLC GIPR / GLP-1R / GCGR Signaling: EC₅₀ 0.064 / 0.775 / 5.79 nM at human receptors (cAMP) Energy-Homeostasis Research: 5 mg lyophilized peptide for in vitro and animal-model investigation Manufacturer: RiboCore Availability: 100 in stock SKU: RP-RETA-5MG $69.00 Qty: Add to cart Ship to Select country United States of America Afghanistan Åland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia (Plurinational State of) Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cabo Verde Cambodia Cameroon Canada Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo (Democratic Republic of the) Cook Islands Costa Rica Côte d'Ivoire Croatia Cuba Curaçao Cyprus Czechia Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Eswatini Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See Honduras Hong Kong Hungary Iceland India Indonesia Iran (Islamic Republic of) Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea (Democratic People's Republic of) Korea (Republic of) Kuwait Kyrgyzstan Lao People's Democratic Republic Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Micronesia (Federated States of) Moldova (Republic of) Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Palestine, State of Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Puerto Rico Qatar Réunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Sweden Switzerland Syrian Arab Republic Taiwan, Province of China Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom of Great Britain and Northern Ireland United States Minor Outlying Islands Uruguay Uzbekistan Vanuatu Venezuela (Bolivarian Republic of) Vietnam Virgin Islands (British) Virgin Islands (U.S.) Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe * Other * Shipping Method Name Estimated Delivery Price No shipping options Apply Custom wishlist OK Add to wishlist Add to compare list Email a friend Technical Specifications CharacteristicValue CAS Number2381089-83-2 Molecular FormulaC₂₂₁H₃₄₂N₄₆O₆₈ Molecular Weight4,731.33 Da Purity≥95% (HPLC verified) FormLyophilized powder, 5 mg per vial Retatrutide (LY3437943) is a 39-amino acid synthetic peptide engineered as a triple agonist of the GIPR, GLP-1R, and GCGR class B1 G-protein-coupled receptors. Supplied as a lyophilized powder for in vitro research, this product is provided strictly to qualified researchers for laboratory and animal-model investigation. Certificate of Analysis (CoA) provided with every lot. Not for human or veterinary consumption. Key Research Highlights Research AreaKey Finding Receptor PharmacologyEC₅₀ 0.064 nM (GIPR), 0.775 nM (GLP-1R), 5.79 nM (GCGR) in cAMP assays (Coskun et al., 2022) Structural BiologyCryo-EM structures of all three receptor complexes at 2.68–3.26 Å resolution (Li et al., 2024) Clinical InvestigationPhase 3 investigational compound under the TRIUMPH registrational program Hepatic Lipid ResearchStudied in MASLD models for lipid-metabolism pathway investigation (Sanyal et al., 2024) Research Applications Triple incretin receptor pharmacology and Gs-coupled cAMP signaling research Class B1 GPCR structural biology and cryo-EM investigation Energy-balance and body-composition research in animal models Metabolic dysfunction-associated steatotic liver disease (MASLD) models Thermogenic gene-expression and brown adipose tissue research Beta-cell function and glucose-dependent insulin signaling studies Receptor desensitization, trafficking, and biased-agonism investigation Research Use Only. This product is supplied for in vitro laboratory investigation by qualified researchers. Not for human or veterinary consumption, diagnosis, treatment, prevention, or cure of any condition. Not approved by the FDA for human use.
