Epithalon (Epitalon)

Pineal Tetrapeptide: 4-amino acid sequence (AEDG), ≥99% purity, naturally occurring compound
Telomerase Activation: hTERT upregulation, telomere elongation, dual pathway mechanism
Geroprotective Research: Pineal melatonin biosynthesis, circadian rhythm regulation, antioxidant defense

Manufacturer: RiboCore

Availability: In stock

SKU: RC-EPITALON-10MG

$32.00

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Technical Specifications

Characteristic	Value
CAS Number	307297-39-8
Molecular Weight	390.35 Da
Purity	≥99% (HPLC)
Form	Lyophilized white powder
Net Peptide Content	10 mg per vial

Epitalon (Epithalon, Epithalone) is a synthetic tetrapeptide comprising four amino acid residues (Ala-Glu-Asp-Gly) with the single-letter code AEDG. Originally synthesized in the 1980s by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Epitalon was designed based on the amino acid composition of Epithalamin, a bioactive extract from the bovine pineal gland. In 2017, the peptide was detected for the first time in physiological pineal gland extract using liquid chromatography-mass spectrometry (LC-MS), confirming its status as a naturally occurring endogenous compound.

Over more than four decades of research, Epitalon has accumulated a substantial body of peer-reviewed literature spanning telomerase biology, chronobiology, neuroendocrine regulation, reproductive aging, ophthalmic science, immunomodulation, and gerontology. A comprehensive review published in the International Journal of Molecular Sciences in 2025 catalogued the breadth of Epitalon research, characterizing the peptide as possessing \"significant geroprotective and neuroendocrine effects\" arising from antioxidant, neuroprotective, and antimutagenic mechanisms.

Key Research Highlights

Research Area	Key Finding
Telomerase Activation	12-fold hTERT upregulation in 21NT cells; 5-fold in BT474 cells; telomere elongation from 2.4 kb to 4 kb (Al-dulaimi et al., 2025)
Oocyte Aging Protection	Reduced intracellular ROS 7.5-fold (from 32.8 to 4.4, P<0.001); decreased early apoptosis from 39.56% to 26.23% (Yue et al., 2022)
Diabetic Retinopathy	Restored wound healing in high glucose-injured ARPE-19 retinal cells; reduced H2O2 generation (P<0.05 to P<0.01) (Gatta et al., 2025)
Anti-inflammatory	Reduced LPS-stimulated TNF-alpha, IL-6, and IL-17 in differentiated THP-1 macrophages (Avolio et al., 2022)

Research Applications

Telomere biology and cellular senescence research
Chronobiology and circadian rhythm studies
Reproductive aging and gamete quality research
Epigenetic regulation and chromatin remodeling studies
Oxidative stress and antioxidant defense research
Neuroendocrine regulation and pineal function
Ophthalmic research and retinal health
Inflammatory modulation in monocyte/macrophage systems