B-12 (10ml)

Essential Cobalt-Containing Vitamin: Cyanocobalamin (C₆₃H₈₈CoN₁₄O₁₄P), 1000 mcg/mL injectable solution
Methylation Pathway Cofactor: Critical for methionine synthase and methylmalonyl-CoA mutase enzymatic reactions
Neurological Research Tool: Supports studies in myelin synthesis, DNA methylation, and neuroprotection

Manufacturer: RiboCore

Availability: In stock

SKU: RC-B-12-10ML

$59.00

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Technical Specifications

Characteristic	Value
CAS Number	68-19-9
Molecular Weight	1355.37 Da
Purity	≥98% (HPLC verified)
Form	Sterile aqueous solution, 1000 mcg/mL
Volume	10 mL multi-dose vial

Vitamin B-12 (cyanocobalamin) is a cobalt-containing water-soluble vitamin essential for cellular metabolism, neurological function, and hematopoiesis. With thousands of peer-reviewed publications spanning over seven decades since its isolation in 1948, cobalamin remains one of the most extensively studied micronutrients in biomedical science. Injectable formulations bypass gastrointestinal absorption limitations, making them particularly valuable for research into pernicious anemia, malabsorption syndromes, and age-related neurological decline.

The molecule features a unique corrin ring structure with a central cobalt atom, enabling B-12 to participate in two essential enzymatic reactions: methionine synthase (requiring methylcobalamin) catalyzes homocysteine remethylation to methionine, while methylmalonyl-CoA mutase (requiring adenosylcobalamin) converts methylmalonyl-CoA to succinyl-CoA for lipid metabolism and myelin synthesis.

Key Research Highlights

Research Area	Key Finding
DNA Methylation	Brain B-12 depletion (90% over 20 weeks) correlates with 40% decrease in global DNA methylation in animal models
Neurological Function	Methylcobalamin demonstrates efficacy for neuropathic pain through inflammatory cytokine suppression and ion channel modulation
Hematopoiesis	Effective therapy may reverse megaloblastic anemia laboratory abnormalities within 24 hours
Bioavailability	IM route achieves near 100% bioavailability with peak plasma concentration within 1 hour

Research Applications

Methylation pathway and one-carbon metabolism studies
Epigenetic regulation and DNA methylation pattern analysis
Neurological function and neuroprotection research
Hematological research and megaloblastic anemia models
Drug delivery and bioconjugate chemistry investigations
Gastrointestinal absorption and transport mechanism studies
Comparative route-of-administration pharmacology
Peripheral neuropathic pain modulation pathway research