AOD9604 6mg

Synthetic hGH Fragment: 16-amino acid C-terminal peptide (177-191), ≥98% purity
Beta-3-AR Upregulation: Enhances lipolysis while suppressing lipogenesis without IGF-1 elevation
Metabolic Research: Six human trials (900+ participants), FDA GRAS status

Manufacturer: RiboCore

Availability: In stock

SKU: RC-AOD-9604-5MG

$48.00

Ship to

Shipping Method

Estimated Delivery

Price

No shipping options

Technical Specifications

Characteristic	Value
CAS Number	221231-10-3
Molecular Weight	1815.10 Da
Purity	≥98% (HPLC)
Form	Lyophilized powder

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino acid peptide fragment derived from the C-terminal region of human growth hormone (hGH), corresponding to amino acids 177-191 with an additional N-terminal tyrosine residue. Originally developed in the early 1990s by Professor Frank Ng at Monash University in Australia, this peptide was engineered to isolate the lipolytic properties of growth hormone while eliminating growth-promoting, diabetogenic, and IGF-1-stimulating effects.

The peptide has been extensively studied through research spanning more than three decades, including six randomized, double-blind, placebo-controlled human clinical trials involving over 900 participants. It has been assigned Generally Recognized As Safe (GRAS) status by the FDA. Emerging research has extended interest into musculoskeletal medicine, with reviews identifying AOD-9604 among key peptides for chondrogenic induction and cartilage regeneration in osteoarthritis.

Key Research Highlights

Research Area	Key Finding
Body Weight Regulation	Over 50% reduction in body weight gain in obese Zucker rats (15.8 vs. 35.6 g in controls) with 500 µg/kg daily dosing
Beta-3-AR Expression	Restored beta-3-adrenergic receptor mRNA expression in obese mice to levels comparable with lean animals
Metabolic Selectivity	No effect on insulin sensitivity, serum IGF-1 levels, or glucose tolerance across multiple species and human trials
Cartilage Research	Combined AOD-9604 and hyaluronic acid injections showed significantly lower gross morphological and histopathological scores in rabbit osteoarthritis models

Research Applications

Beta-3-adrenergic receptor signaling and adipose tissue regulation studies
Lipolysis and lipogenesis pathway investigation in metabolic research
Growth hormone fragment biology and structure-activity relationships
Mitochondrial fatty acid oxidation and energy expenditure studies
Cartilage regeneration and chondrogenic induction research
Obesity and metabolic syndrome preclinical models
Peptide pharmacology, oral bioavailability, and drug development
Safety pharmacology frameworks for bioactive peptides