5-Amino-1MQ 50mg (60 Capsules)

NNMT Inhibitor: Small-molecule inhibitor of nicotinamide N-methyltransferase (IC50 = 1.2 μM), ≥98% purity
NAD+ Salvage Enhancement: Preserves nicotinamide for NAD+ biosynthesis; elevates intracellular NAD+ by 1.2-1.6-fold
Metabolic Research: Studied in obesity, muscle aging, cardiovascular function, and neurodegenerative disease models

Manufacturer: RiboCore

Availability: In stock

SKU: RC-5-AMINO-1MQ-50MG-60-

$99.00

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Technical Specifications

Characteristic	Value
CAS Number	42464-96-0
Molecular Weight	159.21 g/mol (free base)
Purity	≥98% (HPLC)
Form	50 mg capsules (60 count)
IC50	1.2 ± 0.1 μM (NNMT inhibition)

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism, methylation homeostasis, and aging biology. First described by Neelakantan et al. in 2017 as a structure-guided optimization of the methylquinolinium scaffold, 5-Amino-1MQ represents a ten-fold improvement in inhibitory potency over its parent compound. Unlike traditional peptides, 5-Amino-1MQ is a cell-permeable quinoline derivative with exceptional target selectivity and demonstrated oral bioavailability (38.4% in preclinical models).

Over the past nine years, research on 5-Amino-1MQ has expanded across multiple therapeutic domains including diet-induced obesity, type 2 diabetes, muscle aging and sarcopenia, cardiovascular disease, neurodegenerative disease, and cancer metabolism. Notable developments in 2025 include the first preclinical study demonstrating NNMT inhibition improves cardiac function in a heart failure model. As of February 2026, no human clinical trials have been registered, and the compound remains classified as an investigational research chemical.

Key Research Highlights

Research Area	Key Finding
Obesity Models	Treatment reduced body weight by ~5.1%, epididymal fat pad mass by ~35%, and plasma cholesterol by ~30% in diet-induced obese mice (Neelakantan et al., 2017)
Muscle Aging	Increased proliferating muscle stem cells by 60-75% in aged mice; myofiber cross-sectional area increased 1.8-fold post-injury (Neelakantan et al., 2019)
Exercise Synergy	NNMTi-treated sedentary mice showed ~40% greater grip strength than controls; combined with exercise, ~60% improvement (Dimet-Wiley et al., 2024)
Cardiac Function	NNMT inhibition reduced cardiac 1-MNA by 77.1%, improved cardiac function, and decreased left ventricular hypertrophy and fibrosis (Li et al., 2025)

Research Applications

NAD+ metabolism and cellular bioenergetics
Adipose tissue biology and diet-induced obesity models
Type 2 diabetes and insulin resistance research
Aging and longevity studies
Muscle physiology and sarcopenia investigations
Cardiovascular disease pathogenesis
Neurodegenerative disease models (Parkinson's, Alzheimer's, Huntington's)
Cancer metabolism and oncology research